Tri-Luma® Cream is indicated for the short-term (8 week) treatment of moderate to severe melasma of the face. Tri-Luma® Cream should be used with measures for sun avoidance, like using sunscreen of SPF 30 or higher. Tri-Luma® Cream contains sulfites which may cause severe, life-threatening allergic reactions, so tell your doctor if you are allergic to sulfites. Tri-Luma® Cream contains hydroquinone, which may cause a gradual blue-black darkening of the skin. If you are pregnant, nursing or trying to become pregnant you should not use Tri-Luma® Cream. Safety and efficacy have not been established in individuals with darker skin. Reversible HPA axis (adrenal function) suppression may result from exposure to the topical corticosteroid, fluocinolone acetonide, so discontinue use if signs or symptoms of this condition occur. In addition, redness, peeling, burning, dryness and itching may occur. Exposure to sunlight, sunlamps, or UV light and extreme heat, wind, or cold should be avoided. Tri-Luma® Cream should not be used with irritating products such as abrasive cleansers, scrubs, or skin-peeling agents.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. For more information about Tri-Luma® Cream, please see full Prescribing Information.

About Melasma

Don’t stay in the dark about this common skin condition—learn more about melasma.
Can melasma be prevented?

There isn’t a medication or skin care regimen that can prevent melasma in every case, but there are measures you can take that may help reduce your risk of developing melasma.

Melasma may become darker when skin is exposed to the sun. Minimizing your exposure to sunlight can help prevent further darkening of existing melasma as well as the formation of new patches. This is especially important for women who take birth control pills or hormone replacement supplements, and for people who have had melasma in the past.

If you are in the sun for long periods of time, wear a hat that completely shades your face. To help prevent melasma, most dermatologists recommend wearing sunscreen every day. Look for one that offers broad-spectrum protection (that means it blocks both UVA and UVB rays), and has an SPF (sun protection factor) of 15 or higher.

Even the level of sun exposure you can get from sitting next to a window can be enough to trigger melasma if your skin is unprotected, so it’s critical to wear sunscreen every day, regardless of whether or not you plan on being outdoors.

IMPORTANT SAFETY INFORMATION

Tri-Luma® Cream is indicated for the short-term (8 week) treatment of moderate to severe melasma of the face. Tri-Luma® Cream should be used with measures for sun avoidance, like using sunscreen of SPF 30 or higher. Tri-Luma® Cream contains sulfites which may cause severe, life-threatening allergic reactions, so tell your doctor if you are allergic to sulfites. Tri-Luma® Cream contains hydroquinone, which may cause a gradual blue-black darkening of the skin. If you are pregnant, nursing or trying to become pregnant you should not use Tri-Luma® Cream. Safety and efficacy have not been established in individuals with darker skin. Reversible HPA axis (adrenal function) suppression may result from exposure to the topical corticosteroid, fluocinolone acetonide, so discontinue use if signs or symptoms of this condition occur. In addition, redness, peeling, burning, dryness and itching may occur. Exposure to sunlight, sunlamps, or UV light and extreme heat, wind, or cold should be avoided. Tri-Luma® Cream should not be used with irritating products such as abrasive cleansers, scrubs, or skin-peeling agents.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch,
or call 1-800-FDA-1088. For more information about Tri-Luma® Cream, please see full Prescribing Information.
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